What is DHEA? Supplementation, indications and contraindications

Nowadays, we pay more and more attention to health and ways to improve it. One of the supplements that has gained popularity in recent years is DHEA. Before you decide to use it, it is worth taking a closer look at what exactly DHEA is, what is his indications and potential contraindications.

What is DHEA?

Dehydroepiandrosterone (DHEA) is a steroid hormone naturally found in the human body, mainly produced by the adrenal corage, as well as in smaller quantities by the ovaries and testicles. DHEA is a precursor of other important sex hormones, such as estrogens and testosterone. Its concentration reaches a maximum level of around 20 years old, and then begins to gradually decrease, which is associated with the aging process of the body. Biologically, DHEA plays an important role in regulating functions such as:

• Production of sex hormones: as a precursor of estrogens and testosterone, DHEA is important for maintaining reproductive functions.
• Impact on the immune system: Research suggests that DHEA can modulate an immune response.
• Impact on mood and energy: there is evidence that DHEA can affect the mood, well -being and energy level.

DHEA supplementation - for whom?

DHEA supplementation can be beneficial in various situations and for different groups of people. This is particularly important when the natural production of this hormone is reduced due to age or certain disease states. Here are some of the cases in which DHEA supplementation can be indicated:

Older people

With age, the natural level of DHEA decreases, which can lead to various health problems. DHEA supplementation can help improve overall health and prevent certain age -related diseases such as osteoporosis and mood disorders.

Hormonal disorders

Women suffering from polycystic ovary syndrome (PCOS) may have reduced DHEA levels, which can affect their reproductive health. In this case, DHEA supplementation can support hormonal balance.

Autoimmune diseases

Studies suggest that people with autoimmune diseases such as systemic lupus erythematosus may have reduced DHEA levels. DHEA therapeutic supplementation can help in the modulation of the immune system.

Fertility problems

There is evidence that DHEA supplementation may increase the chances of success in the treatment of infertility, especially in older women of reproductive age.

DHEA - side effects, indications and contraindications

DHEA side effects

Like any supplement, DHEA can cause side effects, especially when it is taken in high doses or for a long time. The most frequently reported negative effects include:

• Acne: An increase in androgens levels can lead to acne development. Increasing hair: As a result of the growth of androgens, there may be an increase in hair in women (hirsutism).
• Mood disorders: High DHEA levels can affect the mood, causing excessive stimulation or anxiety.
• Irregularities in the menstrual cycle: Women may have irregular menstrual cycles.
• Cardiological effects: A potential increase in the risk of cardiovascular problems, although there is a need for further research in this area.

Indications for the use of DHEA

When can we consider DHEA supplementation? Here are some of the main indications:

• DHEA deficiency: Laboratory confirmed DHEA deficiency, especially in the elderly.
• Mood disorders: Symptoms of depression, especially in the elderly, where supplementation can improve mood and cognitive functions.
• Libido problems: Especially in older people with low levels of sex hormones.
• Hormonal disorders: Like PCOS or other lack of hormonal balance. Supporting infertility treatment: especially in the case of a low ovarian reserve.

Contraindications for the use of DHEA

Although DHEA supplementation can be beneficial in many cases, there are also some contraindications:

• Cancer: People with breast, prostate or other hormone -dependent cancer should avoid DHEA supplementation.
• Pregnancy and breastfeeding: The safety of DHEA's use in these periods has not been tested sufficiently.
• Mental disorders: People with the history of mental disorders, such as Mania or schizophrenia, should be careful.
• Liver disease: Long -term DHEA supplementation can affect the liver function.

DHEA supplementation - dosage

The correct dosage of DHEA depends on many factors, such as age, gender, health and individual needs of the patient. General guidelines suggest that doses for the elderly usually range from 25 to 50 mg per day, but they require monitoring and adaptation based on laboratory test results. In the case of deficiencies or specific diseases, therapeutic doses may be higher, but should always be determined by a doctor. Women with PCOS most often use doses from 25 to 75 mg per day, depending on individual needs. Infertility treatment usually includes doses in the range of 25 to 75 mg per day a few months before planned fertilization.

Recommendations for safe use

• Initial dose: start with a minimum dose to assess the body's response.
• Consultation with a doctor: Always consult a doctor before starting supplementation, especially if you have any existing diseases.
• Monitoring: Regular blood tests can help monitor hormone levels and dose adjustment.

The latest research on DHEA

Recent studies on DHEA indicate various potential health benefits, but also highlight the need for further research. For example, in the context of osteoporosis, studies suggest that DHEA can improve bone mineral density in older women and men, which in turn reduces the risk of fractures. In the field of mental health, some studies have a beneficial effect of DHEA on the symptoms of depression and improvement of cognitive function in the elderly. There are also hypotheses that DHEA supplementation may delay the aging process, although further research is needed to confirm these results.

Summary

DHEA is an important hormone affecting many aspects of health, from the production of sex hormones to cognitive functions and mood. DHEA supplementation can be beneficial for deficiencies caused by aging, hormonal disorders and other diseases. However, like any supplement, DHEA can cause side effects and has some contraindications. Proper dosage and regular monitoring of hormone levels are crucial for safe use.

Sources

Labrie, F., & et al. (1995). Effect of dehydroepiandrosterone in postmenopausal women. Journal of Clinical Endocrinology & Metabolism. Morales, A. J., & et al. (1994). Effects of replacement dose of dehydroepiandrosterone in men and world of advancing age. Journal of Clinical Endocrinology & Metabolism.