Charte claw properties: Natural support of joints and spine

Charm claw (Harpagophytum Procumbens), also known as a common graham, is a photocopier from the dry climate of the Kalahari desert and the surrounding South African savanans. Its characteristic, hooked fruit gained the name of "Crushed claw" due to the shape of hard, black spikes, which she attaches to animal hair. For centuries, this plant has been used by African Batu and Ovaherero tribes to treat joint ailments, rheumatic pains and digestive disorders. Over time, its operation was popularized by colonial missions, and the beginning of the 20th century brought the first attempts to standardize extracts on active ingredients.

The main group of bioactive substances of the devil's claw are iridoids - above all harpagosyd (approx. 1-3% dry root mass) and other derivatives of harpagidic acid. In addition, the plant contains phenolocuts, proanthocyanidine, phytosterols and saponins, which give it an anti -inflammatory and analgesic profile. The root of the devil's claw is also a source of minerals such as iron and magnesium, and mucus that can alleviate gastrointestinal irritations.

Water-alcohol extracts with a standardized content of harpagosdes have become the basis of modern phytotherapeutic preparations for adult patients suffering from musculoskeletal disorders. Thanks to the synergy of iridoids and polyphenols, the Czarci Claw has a comparable effect to some nonsteroidal anti -inflammatory drugs (NLPZ), but with a much lower risk of gastrointestinal and kidney side effects.

In this guide we will discuss in detail: where the charm claw comes from and what substances are responsible for its activity; anti -inflammatory and analgesic mechanisms; practical applications in joint pain, spine and rheumatoid arthritis (RA); Dosage rules and form of preparations; contraindications and possible side effects; as well as an overview of the most important clinical trials assessing the effectiveness of the plant. Thanks to this, you will gain a full picture of how to safely and effectively use the charm claw in everyday therapy supporting joint and spine health.

Czarci Claw - where does it come from and what does it contain?

The devil's claw naturally occurs in southwestern Africa, in the areas of Namibia, Botswana and South Africa. The plant prefers sandy and semi -desert soils, where its root can reach up to 50 cm deep in search of moisture. Botanics distinguish two species: Harpagophytum Procumbens and Harpagophytum Zeyheri, however, in terms of chemical composition, both have a similar content of iridoids and flavonoids.

In healing prospectus, dried root and kączyn are used as a pharmaceutical raw material, from which water-alcohol extracts are prepared, standardized on harpagosyd (usually 60-120 mg in a daily dose) and other active iridoids (harpagid, Procumbid). In addition, the root includes: coffee acid and chlorogenic acid, proanthocyanidine (catechins and epicatechins), phenolocular and vegetable mucus, which supports the soothing of gastrointestinal irritation.

Iridaoid is a cinematographer-cigaretate-operanantrene, which participate in inhibiting the enzymes responsible for the synthesis of inflammatory mediators, such as cyclooxygenase (COX) and lipooxygenase (LOX). Harpagosyd also shows the ability to connect to MU opioid receptors, which translates into an analgesic effect. Flavonoids and phenolocular acids strengthen the effects of iridoids, neutralizing free radicals and limiting oxidative stress in joint tissues.

In total, the Chata Claw root contains: 1-3% iridoids, 3-5% proanthocyanidin, approx. 1% flavonoids as well as mucus and polyphenols. This composition makes it a valuable raw material supporting the treatment of chronic inflammation and mechanical pain of the musculoskeletal system.

To sum up, the Czarci Claw is an African photocopier rich in Harpagosydy and polyphenols, which thanks to careful extraction and standardization has become a key component of phytotherapeutic preparations for joint discomfort.

CZEW CABLE PAINT AND Anti -inflammatory properties

The anti -inflammatory effect of Chata Pazura is based on inhibiting enzymatic reactions leading to the synthesis of prostaglandin and leukotriens - mediators of pain and inflammation. In vitro studies have shown that extracts containing Harpagosyd and Harpagid inhibit the activity of cyclooxygenase-2 (COX-2) and lipooxygenase-5 (5 -lox), which translates into limitation of the production of pro-inflammatory leukotrienic acid.
In addition, the devil's claw reduces the concentration of pro-inflammatory cytokinins (TNF-α, IL-1β, IL-6) and stabilizes lysosomal membranes, which limits the release of degrading proteolytic enzymes in places of inflammation. Such a multi -track action makes extracts effective in reducing pain and swelling, and at the same time do not lead to damage to the gastrointestinal mucosa, characteristic of NSAID therapy.
The analgesic effect is strengthened by the modulation of opioid receptors-Harpagosyd shows affinity for μ-opioid receptors, which increases the threshold of pain feeling and improves motion comfort. In comparative studies, patients receiving a standardized Extract from Chata Claw felt a comparable placebo relief in combination with NSAIDs, but rarely reported side effects.
The anti -inflammatory and analgesic effect of the devil's claw is particularly valued in chronic therapies, where the long -term use of NSAIDs carries the risk of stomach ulcers and kidney damage. Phytotherapeutic preparations from Crusze Pazura are a safer alternative or supplementing standard treatment.

Application in joint, spine and RA

The devil's claw is widely used in relieving the symptoms of osteoarthritis (osteoartrosis), lumbar pain of the spine and rheumatoid arthritis (RA). Its anti -inflammatory effect contributes to the reduction of swelling and stiffness of the joints, while the analgesic effect improves patient mobility.
In osteoartosis, knees and hips extracts from the devil's claw reduce the feeling of pain during movement and support the reconstruction of cartilage, thanks to the neutralization of free radicals and inhibiting enzymes degrading proteoglycans. In spine pain (here, especially lumbar), phytotherapeutic preparations improve the ability to perform daily activities and reduce the recovery time after musculoskeletal overloads.
In the case of RA, where chronic autoimmune processes lead to the destruction of joints, the charm claw can be used as supporting therapy - limits the production of pro -inflammatory cytokines and slows down the progress of destructive changes. Patients combining the treatment of methotrexate or biological drugs with Extracts from Crusze Pazura have noticed less intensity of pain and a decrease in doses of synthetic drugs.
Due to the variety of mechanisms of action, charm claw is an effective tool in a comprehensive approach to joint pain and spine, both in degenerative and inflammatory diseases.

How to use a devil's claw: doses, forms, length of therapy

The most commonly used form is the standardized water-alcohol extract, containing 50-70 mg of harpagosdes per daily dose (400-600 mg of extract). Preparations are available in the form of tablets, capsules or drops. The standard daily dose is 600-1200 mg of extract, divided into 2-3 parties.

For people who prefer natural methods, root infusions are also helpful: 1-2 teaspoons of dried dried 200-250 ml of boiling water, brewed covered 10-15 minutes. The infusion is drunk 2-3 times a day, but its bioavailability of harpagosdes is lower than in standardized extracts.

Alcohol tinctures (1 part of dried fruit for 5 parts 40% alcohol, macerated 14 days) allow precise dosage - 20-30 drops diluted in water 2-3 times a day. Therapies can be carried out for 8-12 weeks, after which a month break is recommended to avoid the body's habit.

Short claw treatments are best started from lower doses (400 mg of extract or 10 drops of tincture) and gradually increase them to therapeutic level, observing the reactions. Regularity and length of therapy depend on the severity of the ailments - in chronic diseases, cyclical therapies are recommended: 2-3 months of treatment, 1 month break.

Contraindications and possible side effects

The devil's claw is well tolerated by most people, but there are groups that require caution:

• Gastric and duodenal ulcer diseases - iridoids can irritate the mucosa.
• Pregnancy and breastfeeding - lack of sufficient data confirming security.
• Ballstone's obstruction and cholelithiasis - It can cause bile ducts.
• Drug interactions - Possible severity of hypotensive, diabetic and anticoagulant drugs.

The most common side effects include mild gastrointestinal ailments (nausea, diarrhea) and allergic rashes in hypersensitive people. In the event of disturbing symptoms, stop the treatment and consult a doctor.

What do scientific research say about the effectiveness of a devil's claw?

In numerous randomized clinical trials, the effectiveness of the devil's claw in joint and spine pain was confirmed. In the study, Chrubasik et al. (2003) Patients with lower spine pain taking the extract for 4 weeks noted significant relief compared to the placebo group. Similar results were obtained in the therapy of knee osteoartrosis - reduction of pain evaluated with the VAS scale and improvement of the range of motion.
Meta-Analisation covering 5 RCT showed that the charm claw reduces joint pain by an average of 30% compared to placebo and is better tolerated than NSAIDs. In vitro studies confirm the braking of COX-2 and 5 -lox, which confirms the mechanic basics of the anti-inflammatory effect.
To sum up, clinical data clearly indicate that the charm claw is an effective and safe supplement supporting the treatment of joint pain, spine and rheumatic diseases.

FAQ

1. Can the charm claw be used every day for a long time?

Yes, the Carci Claw treatments can be carried out cyclically: 8-12 weeks of therapy, followed by a break of 4 weeks. Longer, continuous use without a break can lead to a decrease in the effectiveness and occurrence of side effects.

2. How quickly is the relief after starting the therapy of a charm claw?

The first analgesic effects often appear after 1-2 weeks of regularly taking the standardized extract on Harpagosyd. Maximum improvement in joint dynamics and reduction of edema may require 4-6 weeks of use.

3. Does the devil's claw help with back pain resulting from a sitting lifestyle?

Yes, thanks to the anti -inflammatory and analgesic effect, the crab claw can reduce muscle tone and pain in the lower spine in people leading a sedentary lifestyle. It is worth combining supplementation with exercises strengthening deep back muscles.

4

Standardized water-alcohol extracts in capsules or tablets, containing a certain number of harpagosdes (50-70 mg/d), show the best bioavailability. Infusions and tinctures provide lower concentrations, but they can be a useful complement to therapy.

5. Can the devil's claw interact with painkillers?

The devil's claw can intensify the effects of painkillers and anti -inflammatory drugs, so when using it, it is worth consulting a doctor and monitoring any side effects. It can also affect anticoagulant and hypotensive drugs.

6. Is the devil's claw recommended for rheumatoid arthritis?

Yes, clinical trials indicate the benefits of the use of Cruta Pazura as a supporting therapy in RA - reduction of pain and joint stiffness of the joints. It should always be used next to drugs modifying the course of the disease, under the control of a rheumatologist.

7. Does the charm claw antioxidant?

Yes, the phenolocular and proanthocyanidins contained in the plant neutralize free radicals and protect the cells of articular tissue from oxidative stress, which supports the protection of cartilage and slows down the degenerative process.

Sources

• Chrubasik S., et al., "Efficacy and tolerability of Harpagophytum Procumbens in Osteoarthritis: A Systematic Review", Phytomedicine. 2003.
• Rettig J., "Devil's Claw (Harpagophytum Procumbens) Monograph", Escop Monographs. 2009.
• Wright C., "Clinical Trials on Devil’s Claw in Low Back Pain", Journal of Rheumatology. 2004.
• Healthline.com, "Devil’s Claw Benefits, Uses, and Side Effects."
• Pubchem, "Harpagophytum Procumbens Compound Summary."